Copy number variations at LEPR gene locus associated with gene expression and phenotypic traits in Chinese cattle.

@article{Shi2016CopyNV,
  title={Copy number variations at LEPR gene locus associated with gene expression and phenotypic traits in Chinese cattle.},
  author={Tao Shi and Yao Xu and Mingjuan Yang and Yongzhen Huang and Xianyong Lan and Chuzhao Lei and Xinglei Qi and Xiaoming Yang and Hong Chen},
  journal={Animal science journal = Nihon chikusan Gakkaiho},
  year={2016},
  volume={87 3},
  pages={336-43}
}
Current evidences show that copy number variations (CNVs) are linked to complex phenotypic traits. Leptin receptor (LEPR) gene plays a critical role in energy homeostasis and fat development and re-sequencing of the cattle genome revealed the CNV region (herein referred to as "I3 DNA") within the LEPR intron 3. In the present study, we qualified copy numbers of I3 DNA within LEPR gene in four cattle breeds (Qinchuan, Nanyang, Jinnan and Xianan) by quantitative PCR, and explored their impacts on… CONTINUE READING