Copy-number variations associated with neuropsychiatric conditions
@article{Cook2008CopynumberVA, title={Copy-number variations associated with neuropsychiatric conditions}, author={E. Cook and S. Scherer}, journal={Nature}, year={2008}, volume={455}, pages={919-923} }
Neuropsychiatric conditions such as autism and schizophrenia have long been attributed to genetic alterations, but identifying the genes responsible has proved challenging. Microarray experiments have now revealed abundant copy-number variation — a type of variation in which stretches of DNA are duplicated, deleted and sometimes rearranged — in the human population. Genes affected by copy-number variation are good candidates for research into disease susceptibility. The complexity of… CONTINUE READING
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References
SHOWING 1-10 OF 58 REFERENCES
Genomic Rearrangements and Gene Copy-Number Alterations as a Cause of Nervous System Disorders
- Biology, Medicine
- Neuron
- 2006
- 260
Increase in GSK3β gene copy number variation in bipolar disorder
- Biology, Medicine
- American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
- 2007
- 121
Advances in autism genetics: on the threshold of a new neurobiology
- Biology, Medicine
- Nature Reviews Genetics
- 2008
- 1,615
- PDF
Rare chromosomal deletions and duplications increase risk of schizophrenia
- Biology, Medicine
- Nature
- 2008
- 1,424
- PDF
Rare Structural Variants Disrupt Multiple Genes in Neurodevelopmental Pathways in Schizophrenia
- Biology, Medicine
- Science
- 2008
- 1,650
- PDF
Mapping autism risk loci using genetic linkage and chromosomal rearrangements
- Biology, Medicine
- Nature Genetics
- 2007
- 1,289
- PDF
Strong association of de novo copy number mutations with sporadic schizophrenia
- Biology, Medicine
- Nature Genetics
- 2008
- 805