Copy number variation showers in schizophrenia: an emerging hypothesis

@article{Singh2009CopyNV,
  title={Copy number variation showers in schizophrenia: an emerging hypothesis},
  author={S. M. Singh and Christina A. Castellani and Richard O'reilly},
  journal={Molecular Psychiatry},
  year={2009},
  volume={14},
  pages={356-358}
}
Genetic discoveries on Schizophrenia remain challenging. Traditional approaches have provided clues, but no genes. Novel theories that must account for extensive heterogeneity, including high discordance of monozygotic (MZD) twins, are needed. To this end, the extensive repeats of the human genome may provide the predisposition for DNA replication errors operational at every cell cycle during meiosis and mitosis. These errors will shower the genome with replication errors including copy number… CONTINUE READING