Copy number variation detection in whole-genome sequencing data using the Bayesian information criterion.

@article{Xi2011CopyNV,
  title={Copy number variation detection in whole-genome sequencing data using the Bayesian information criterion.},
  author={Ruibin Xi and Angela G Hadjipanayis and Lovelace J. Luquette and Tae-Min Kim and Eunjung Lee and Jianhua Zhang and Mark D. Johnson and Donna M. Muzny and David A. Wheeler and Richard A. Gibbs and Raju Kucherlapati and Peter J. Park},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 46},
  pages={E1128-36}
}
DNA copy number variations (CNVs) play an important role in the pathogenesis and progression of cancer and confer susceptibility to a variety of human disorders. Array comparative genomic hybridization has been used widely to identify CNVs genome wide, but the next-generation sequencing technology provides an opportunity to characterize CNVs genome wide with unprecedented resolution. In this study, we developed an algorithm to detect CNVs from whole-genome sequencing data and applied it to a… CONTINUE READING
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