Copy number variation-based polymorphism in a new pseudoautosomal region 3 (PAR3) of a human X-chromosome-transposed region (XTR) in the Y chromosome

  title={Copy number variation-based polymorphism in a new pseudoautosomal region 3 (PAR3) of a human X-chromosome-transposed region (XTR) in the Y chromosome},
  author={Avinash M. Veerappa and P. Padakannaya and N. Ramachandra},
  journal={Functional & Integrative Genomics},
  • Avinash M. Veerappa, P. Padakannaya, N. Ramachandra
  • Published 2013
  • Biology, Medicine
  • Functional & Integrative Genomics
  • A 3.5-Mb region of the X chromosome underwent duplication and transposition to the Y chromosome ~5–6 Mya. This X-transposed-region (XTR) originated at Xq21.3 and was inserted at Yp11.2. The two locations have 98.78 % homology and a high concentration of tandem repeats. In whole-genome scans of ten large families with dyslexic members, we identified transposed blocks comprising >102 kb of the Yp11.2 region in its homologous region at Xq21.3 in three females from three different families… CONTINUE READING
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