• DOI:10.1007/s10142-013-0323-6
Corpus ID: 13443194

Copy number variation-based polymorphism in a new pseudoautosomal region 3 (PAR3) of a human X-chromosome-transposed region (XTR) in the Y chromosome

@article{Veerappa2013CopyNV,
  title={Copy number variation-based polymorphism in a new pseudoautosomal region 3 (PAR3) of a human X-chromosome-transposed region (XTR) in the Y chromosome},
  author={Avinash M. Veerappa and P. Padakannaya and N. Ramachandra},
  journal={Functional & Integrative Genomics},
  year={2013},
  volume={13},
  pages={285-293}
}

• Avinash M. Veerappa, P. Padakannaya, N. Ramachandra
• Published 2013
• Biology, Medicine
• Functional & Integrative Genomics

A 3.5-Mb region of the X chromosome underwent duplication and transposition to the Y chromosome ~5–6 Mya. This X-transposed-region (XTR) originated at Xq21.3 and was inserted at Yp11.2. The two locations have 98.78 % homology and a high concentration of tandem repeats. In whole-genome scans of ten large families with dyslexic members, we identified transposed blocks comprising >102 kb of the Yp11.2 region in its homologous region at Xq21.3 in three females from three different families… Expand

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