Copy number variation-based polymorphism in a new pseudoautosomal region 3 (PAR3) of a human X-chromosome-transposed region (XTR) in the Y chromosome

@article{Veerappa2013CopyNV,
  title={Copy number variation-based polymorphism in a new pseudoautosomal region 3 (PAR3) of a human X-chromosome-transposed region (XTR) in the Y chromosome},
  author={Avinash M. Veerappa and Prakash Padakannaya and Nallur B. Ramachandra},
  journal={Functional \& Integrative Genomics},
  year={2013},
  volume={13},
  pages={285-293}
}
A 3.5-Mb region of the X chromosome underwent duplication and transposition to the Y chromosome ~5–6 Mya. This X-transposed-region (XTR) originated at Xq21.3 and was inserted at Yp11.2. The two locations have 98.78 % homology and a high concentration of tandem repeats. In whole-genome scans of ten large families with dyslexic members, we identified transposed blocks comprising >102 kb of the Yp11.2 region in its homologous region at Xq21.3 in three females from three different families… 
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39 Citations

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The evolutionary sequence of events together with the prior case for an X‐Y homologous gene suggests that this gene‐pair is a candidate for the evolution of hominid‐specific characteristics including the sexual dimorphism of cerebral asymmetry, a putative correlate of language.