Copy number imbalances in blood and hair in monozygotic twins discordant for amyotrophic lateral sclerosis.

@article{Pamphlett2011CopyNI,
  title={Copy number imbalances in blood and hair in monozygotic twins discordant for amyotrophic lateral sclerosis.},
  author={Roger Pamphlett and Julia M. Morahan},
  journal={Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia},
  year={2011},
  volume={18 9},
  pages={1231-4}
}
Chromosomal copy number association studies in patients with amyotrophic lateral sclerosis (ALS) using blood DNA have so far been inconclusive. We employed genome-wide screening to look for copy number imbalances (CNIs) between blood and hair DNA from three ALS-discordant monozygotic twin pairs and two phenotypically normal monozygotic twin pairs. Genome-wide chromosomal copy number was estimated using AffyMetrix 6.0 GeneChips. CNIs were sought both between twin pairs and between blood and hair… CONTINUE READING
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