Copy number gains on 5p15, 6p11-q11, 7p12, and 8q24 are rare in sputum cells of individuals at high risk of lung cancer.

@article{Kettunen2006CopyNG,
  title={Copy number gains on 5p15, 6p11-q11, 7p12, and 8q24 are rare in sputum cells of individuals at high risk of lung cancer.},
  author={Eeva Kettunen and Kaisa Salmenkivi and Katri Vuopala and Tuula Toljamo and Eeva Kuosma and Hannu Norppa and Sakari Knuutila and S. I. Kaleva and Matti S. Huuskonen and Sisko Anttila},
  journal={Lung cancer},
  year={2006},
  volume={54 2},
  pages={
          169-76
        }
}
UNLABELLED Lung cancer specimens display recurrent copy number aberrations in distinguished chromosomal regions as compared with normal lung cells. Such alterations have been utilized in design of fluorescence in situ hybridization (FISH) probe sets in attempts to improve the cytological diagnosis of lung cancer. One of such probe sets, LAVysion, detects copy number changes in the centromeric region of chromosome 6 (CEP6), and regions 5p15, 8q24, and 7p12, often gained in lung cancer. METHODS… CONTINUE READING

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