Copy number gain and oncogenic activity of YWHAZ/14-3-3zeta in head and neck squamous cell carcinoma.

@article{Lin2009CopyNG,
  title={Copy number gain and oncogenic activity of YWHAZ/14-3-3zeta in head and neck squamous cell carcinoma.},
  author={Mauting Lin and Carl D. Morrison and Susie Jones and Nehad Helmy Mohamed and Jason Bacher and Christoph Plass},
  journal={International journal of cancer},
  year={2009},
  volume={125 3},
  pages={603-11}
}
Gene amplification, a common mechanism for oncogene activation in cancers, has been used in the discovery of novel oncogenes. Low-level copy number gains are frequently observed in head and neck squamous cell carcinomas (HNSCCs) where numerous amplification events and potential oncogenes have already been reported. Recently, we applied restriction landmark genome scanning to study gene amplifications in HNSCC and located novel and uncharacterized regions in primary tumor samples. Gain on… CONTINUE READING
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