Copy Number Variations in Amyotrophic Lateral Sclerosis: Piecing the Mosaic Tiles Together through a Systems Biology Approach

@article{Morello2017CopyNV,
  title={Copy Number Variations in Amyotrophic Lateral Sclerosis: Piecing the Mosaic Tiles Together through a Systems Biology Approach},
  author={Giovanna Morello and Maria Guarnaccia and Antonio Gianmaria Spampinato and Valentina La Cognata and Velia D’Agata and Sebastiano Cavallaro},
  journal={Molecular Neurobiology},
  year={2017},
  volume={55},
  pages={1299 - 1322}
}
Amyotrophic lateral sclerosis (ALS) is a devastating and still untreatable motor neuron disease. Despite the molecular mechanisms underlying ALS pathogenesis that are still far from being understood, several studies have suggested the importance of a genetic contribution in both familial and sporadic forms of the disease. In addition to single-nucleotide polymorphisms (SNPs), which account for only a limited number of ALS cases, a consistent number of common and rare copy number variations… Expand
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