Copy Number Analysis Identifies Novel Interactions Between Genomic Loci in Ovarian Cancer

@inproceedings{Gorringe2010CopyNA,
  title={Copy Number Analysis Identifies Novel Interactions Between Genomic Loci in Ovarian Cancer},
  author={Kylie L. Gorringe and Joshy George and Michael S Anglesio and Manasa Ramakrishna and Dariush Etemadmoghadam and Prue A. Cowin and Anita Sridhar and Louise H. Williams and Samantha E. Boyle and Nozomu Yanaihara and Aikou Okamoto and Mitsuyoshi Urashima and Gordon K Smyth and Ian G. Campbell and David D. L. Bowtell},
  booktitle={PloS one},
  year={2010}
}
Ovarian cancer is a heterogeneous disease displaying complex genomic alterations, and consequently, it has been difficult to determine the most relevant copy number alterations with the scale of studies to date. We obtained genome-wide copy number alteration (CNA) data from four different SNP array platforms, with a final data set of 398 ovarian tumours, mostly of the serous histological subtype. Frequent CNA aberrations targeted many thousands of genes. However, high-level amplicons and… CONTINUE READING

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