Copy Number Amplification of the PIK3CA Gene Is Associated with Poor Prognosis in Non-lymph node metastatic Head and Neck Squamous Cell Carcinoma

@inproceedings{Suda2012CopyNA,
  title={Copy Number Amplification of the PIK3CA Gene Is Associated with Poor Prognosis in Non-lymph node metastatic Head and Neck Squamous Cell Carcinoma},
  author={Toshihito Suda and Takanori Hama and Shu Kondo and Yuki Yuza and Mamoru Yoshikawa and Mitsuyoshi Urashima and Takakuni Kato and Hiroshi Moriyama},
  booktitle={BMC Cancer},
  year={2012}
}
Deregulation of the EGFR signaling pathway is one of the most frequently observed genetic abnormalities that drives cancer development. Although mutations in the downstream components of the EGFR signaling pathway, including KRAS, BRAF and PIK3CA, have been reported in numerous cancers, extensive mutation and copy number analysis of these genes in clinical samples has not been performed for head and neck squamous cell carcinoma (HNSCC). We examined the mutations and copy number alterations of… CONTINUE READING

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