Copresentation of antigen and ligands of Siglec-G induces B cell tolerance independent of CD22.

@article{Pfrengle2013CopresentationOA,
  title={Copresentation of antigen and ligands of Siglec-G induces B cell tolerance independent of CD22.},
  author={Fabian Pfrengle and Matthew S Macauley and Norihito Kawasaki and James C Paulson},
  journal={Journal of immunology},
  year={2013},
  volume={191 4},
  pages={1724-31}
}
Differentiation of self from nonself is indispensable for maintaining B cell tolerance in peripheral tissues. CD22 and Siglec-G (sialic acid-binding Ig-like lectin G) are two inhibitory coreceptors of the BCR that are implicated in maintenance of tolerance to self Ags. Enforced ligation of CD22 and the BCR by a nanoparticle displaying both Ag and CD22 ligands induces a tolerogenic circuit resulting in apoptosis of the Ag-reactive B cell. Whether Siglec-G also has this property has not been… CONTINUE READING
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