Copper-zinc superoxide dismutase affects Akt activation after transient focal cerebral ischemia in mice.


BACKGROUND AND PURPOSE The serine-threonine kinase Akt is activated by phosphorylation at serine-473. After phosphorylation, activated Akt inactivates BAD or caspase-9 or other apoptogenic components, thereby inhibiting cell death. In this study we examined the relationship between Akt phosphorylation and oxidative stress after transient focal cerebral… (More)

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