Copper transporter CTR1 expression and tissue platinum concentration in non-small cell lung cancer.

@article{Kim2014CopperTC,
  title={Copper transporter CTR1 expression and tissue platinum concentration in non-small cell lung cancer.},
  author={Eric S. Kim and Ximing Tang and Derick R. Peterson and Deepak Kilari and C Chow and Junya Fujimoto and Neda Kalhor and Stephen G Swisher and David J. Stewart and Ignacio Wistuba and Zahid H. Siddik},
  journal={Lung cancer},
  year={2014},
  volume={85 1},
  pages={88-93}
}
BACKGROUND Platinum resistance is a major limitation in the treatment of advanced non-small cell lung cancer (NSCLC). We previously demonstrated that low tissue platinum concentration in NSCLC specimens was significantly associated with reduced tumor response. Furthermore, low expression of the copper transporter CTR1, a transporter of platinum uptake was associated with poor clinical outcome following platinum-based therapy in NSCLC patients. We investigated the relationship between tissue… CONTINUE READING