Corpus ID: 11394607

Copper transfer and activation of the Streptomyces apotyrosinase are mediated through a complex formation between apotyrosinase and its trans-activator MelC1.

@article{Chen1992CopperTA,
  title={Copper transfer and activation of the Streptomyces apotyrosinase are mediated through a complex formation between apotyrosinase and its trans-activator MelC1.},
  author={L. Chen and W. Leu and K. Wang and Y. H. Lee},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 28},
  pages={
          20100-7
        }
}
  • L. Chen, W. Leu, +1 author Y. H. Lee
  • Published 1992
  • Chemistry, Medicine
  • The Journal of biological chemistry
  • The melanin operon (melC) of Streptomyces antibioticus is composed of two genes that encode MelC1 and MelC2 proteins. MelC1 has been suggested as a trans-activator which can facilitate the incorporation of copper into the apotyrosinase (MelC2) (Lee, Y.-H. W., Chen, B.-F., Wu, S.-Y., Leu, W.-M., Lin, J.-J., Chen, C. W., and Lo, S. J. (1988) Gene (Amst.) 65, 71-81). However, the molecular mechanism of the trans-activation or copper-transfer process mediated through MelC1 to MelC2 is not clear yet… CONTINUE READING
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