Copper trafficking to the mitochondrion and assembly of copper metalloenzymes.

@article{Cobine2006CopperTT,
  title={Copper trafficking to the mitochondrion and assembly of copper metalloenzymes.},
  author={Paul A Cobine and Fabien Pierrel and Dennis R Winge},
  journal={Biochimica et biophysica acta},
  year={2006},
  volume={1763 7},
  pages={759-72}
}
Copper is required within the mitochondrion for the function of two metalloenzymes, cytochrome c oxidase (CcO) and superoxide dismutase (Sod1). Copper metallation of these two enzymes occurs within the mitochondrial intermembrane space and is mediated by metallochaperone proteins. Cox17 is a key copper donor to two accessory proteins, Sco1 and Cox11, to form the two copper centers in the mature CcO complex. Ccs1 is the necessary metallochaperone for the copper metallation of Sod1 in the IMS as… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 74 extracted citations

Similar Papers

Loading similar papers…