Copper-trafficking efficacy of copper-pyruvaldehyde bis(N4-methylthiosemicarbazone) on the macular mouse, an animal model of Menkes disease

@article{Munakata2012CoppertraffickingEO,
  title={Copper-trafficking efficacy of copper-pyruvaldehyde bis(N4-methylthiosemicarbazone) on the macular mouse, an animal model of Menkes disease},
  author={Mitsutoshi Munakata and Hiroko Kodama and Chie Fujisawa and Tomoko Hiroki and Kazuhiko Kimura and Mika Watanabe and Masazumi Nishikawa and Shigeru Tsuchiya},
  journal={Pediatric Research},
  year={2012},
  volume={72},
  pages={270-276}
}
Background:Menkes disease (MD) is a disorder of copper transport caused by ATP7A mutations. Although parenteral copper supplements are partly effective in treating MD, the copper level in the brain remains insufficient, whereas copper accumulates in the kidney. We investigated the copper-trafficking efficacy of copper-pyruvaldehyde bis(N4-methylthiosemicarbazone) (Cu-PTSM), a lipophilic copper complex, in macular mice, an animal model of MD.Methods:Macular mice were treated with cupric chloride… CONTINUE READING