Copper toxicity affects proliferation and viability of human hepatoma cells (HepG2 line).

@article{Aston2000CopperTA,
  title={Copper toxicity affects proliferation and viability of human hepatoma cells (HepG2 line).},
  author={N S Aston and N M Watt and Ian Morton and Malcolm S Tanner and Gareth J S Evans},
  journal={Human & experimental toxicology},
  year={2000},
  volume={19 6},
  pages={367-76}
}
In Wilson's disease and Indian childhood cirrhosis (ICC) copper accumulates in the liver resulting in poor hepatocyte regeneration and fibrosis. An inhibition of hepatocyte proliferation and an increase in cell death could account for these outcomes. To establish how the toxicity of this metal ion impacts upon the proliferation and viability of the HepG2 cells they were cultured in 4-32 microM copper(II) sulphate (CuSO4)). These levels were comparable to the circulatory and tissue… CONTINUE READING