Copper toxicity, oxidative stress, and antioxidant nutrients.

@article{Gaetke2003CopperTO,
  title={Copper toxicity, oxidative stress, and antioxidant nutrients.},
  author={Lisa M. Gaetke and Ching Kuang Chow},
  journal={Toxicology},
  year={2003},
  volume={189 1-2},
  pages={147-63}
}
Copper (Cu) is an integral part of many important enzymes involved in a number of vital biological processes. Although normally bound to proteins, Cu may be released and become free to catalyze the formation of highly reactive hydroxyl radicals. Data obtained from in vitro and cell culture studies are largely supportive of Cu's capacity to initiate oxidative damage and interfere with important cellular events. Oxidative damage has been linked to chronic Cu-overload and/or exposure to excess Cu… CONTINUE READING
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