Copper sulphate emesis; a study of afferent pathways from the gastrointestinal tract.

  title={Copper sulphate emesis; a study of afferent pathways from the gastrointestinal tract.},
  author={S. C. Wang and H. L. Borison},
  journal={The American journal of physiology},
  volume={164 2},
V OMITING is a complicated act which involves the coordinated activities of many motor systems of the body including both the somatic and autonomic nervous outflows. The orderly sequential action of the different muscle groups used in emesis has been clearly demonstrated by the now classical work of Cannon (I). Equally complex is the question of the sensory pathways of vomiting. The roles of the numerous afferents investigated by various workers on this problem are not in agreement. Our… 

Tables from this paper

Delineation of vagal emetic pathways: intragastric copper sulfate-induced emesis and viral tract tracing in musk shrews.
  • C. C. Horn, K. Meyers, B. Yates
  • Biology
    American journal of physiology. Regulatory, integrative and comparative physiology
  • 2014
The data indicate that the contribution of vagal pathways to intragastric CuSO4-induced emesis is dose dependent in musk shrews, and the current neural tracing data suggest brain stem anatomical circuits that are activated by GI signaling in themusk shrew.
Vomiting: Neural Mechanisms and Control by Chlorpromazine
Current concepts of the vomiting act are described, the physiologic background of these concepts are reviewed, the clinical evidence of the antiemetic properties of chlorpromazine is presented, and the experimental data in regard to the method of action of this drug are reviewed.
Gastric Emptying
A review of the various clinical options used to elicit gastric emptying, viz. drug-induced emesis, mechanical pharyngeal stimulation, gastric lavage, and catharsis finds that apomorphine and syrup of ipecac are the most frequently used drugs for induction of emesis.
Nausea and vomiting
  • A. Cummins
  • Medicine, Psychology
    The American Journal of Digestive Diseases
  • 2005
Vomiting is a biologically ancient protective function designed to rid the body of noxious ingested materials but like a number of such primitive safeguards its purpose is subject to perversion by a great variety of disease states and functional derangements.
Respiratory mechanics of vomiting in decerebrate cats.
Results obtained with spinal cord section at T, and phrenicotomy support the conclusions that the diaphragm, acting in concert with the inspiratory muscles against a closed glottis, is responsible for the negative intrathoracic pressure produced in retching; and that the abdominal musculature isresponsible for the positive pressure generated in the abdomen during retching and expulsion.
Induced vomiting : a therapeutic option
The anatomy of brain structures containing the vomiting reflex, including chemoreceptor trigger zone, vomiting center and the specific signal deliver process are described, drawing a conclusion that induced vomiting may be a therapeutic option.
Relationship between small intestinal fasting motility and vomiting in dogs
Coincident with spontaneously occurring vomiting, a statistically significative greater number of responses to both emetic agents was observed during phase II as compared to phase I, which suggests that cyclic changes of the small bowel motility are related to changes in the threshold of the vomiting center.


Am. J. Physiol. I: F. R. J. Physiol
  • Am. J. Physiol. I: F. R. J. Physiol
  • Med
  • 1940
Am. J. Physiol
  • Am. J. Physiol
  • 1931
Am. J. Physiol
  • Am. J. Physiol
  • 1929
J. Cl&. Investigation II
  • J. Cl&. Investigation II
  • 1932
  • . Arch Surg .
Am. J. Path
  • Am. J. Path
Am. J. Physiol
  • Am. J. Physiol
  • 1947
Am. J. Physiol
  • Am. J. Physiol
  • 1945
Arch Int. Med
  • Arch Int. Med