Copper stimulates the release of luteinizing hormone releasing hormone from isolated hypothalamic granules.


Copper, administered to female rabbits, stimulates LHRH release into the hypophyseal portal blood (5) and induces ovulation (1-3). To gain further understanding of the mechanism of action of copper, in this study we addressed the question: Does copper, in the form of CuATP, stimulate LHRH release from isolated hypothalamic granules? Isolated hypothalamic… (More)


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