Copper pathways in Plasmodium falciparum infected erythrocytes indicate an efflux role for the copper P-ATPase.

@article{Rasoloson2004CopperPI,
  title={Copper pathways in Plasmodium falciparum infected erythrocytes indicate an efflux role for the copper P-ATPase.},
  author={D. Rasoloson and Lirong Shi and C. Chong and B. F. Kafsack and D. Sullivan},
  journal={The Biochemical journal},
  year={2004},
  volume={381 Pt 3},
  pages={
          803-11
        }
}
Copper, like iron, is a transition metal that can generate oxygen radicals by the Fenton reaction. The Plasmodium parasite invades an erythrocyte host cell containing 20 microM copper, of which 70% is contained in the Cu/Zn SOD (cuprozinc superoxide dismutase). In the present study, we follow the copper pathways in the Plasmodium-infected erythrocyte. Metal-determination analysis shows that the total copper content of Percoll-purified trophozoite-stage-infected erythrocytes is 66% that of… Expand
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