Copper modulates the phenotypic response of activated BV2 microglia through the release of nitric oxide.

@article{RossiGeorge2012CopperMT,
  title={Copper modulates the phenotypic response of activated BV2 microglia through the release of nitric oxide.},
  author={A. Rossi-George and Changjiang Guo and B. Oakes and A. Gow},
  journal={Nitric oxide : biology and chemistry},
  year={2012},
  volume={27 4},
  pages={
          201-9
        }
}
Microglia are resident immune cells of the central nervous system. Their persistent activation in neurodegenerative diseases, traditionally attributed to neuronal dysfunction, may be due to a microglial failure to modulate the release of cytotoxic mediators such as nitric oxide (NO). The persistent activation of microglia with the subsequent release of NO vis-á-vis the accumulation of redox transition metals such as copper (Cu) in neurodegenerative diseases, prompted the hypothesis that copper… Expand
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