Copper mediated stereoselective synthesis of C-glycosides from unactivated alkynes.

@article{Kusunuru2013CopperMS,
  title={Copper mediated stereoselective synthesis of C-glycosides from unactivated alkynes.},
  author={Anil Kumar Kusunuru and Madhu Babu Tatina and Syed Khalid Yousuf and Debaraj Mukherjee},
  journal={Chemical communications},
  year={2013},
  volume={49 86},
  pages={10154-6}
}
A highly stereoselective rapid C-glycosylation reaction has been developed between glycal and unactivated alkynes in the presence of coppertriflate and ascorbic acid at low catalyst loading and at room temperature. A wide variety of glycals and aryl acetylenes participate in the reaction smoothly. TfOH generated during the reduction of Cu(OTf)2 by ascorbic acid may be the active catalyst for the glycosylation.