Copper-mediated repression of the activation domain in the yeast Mac1p transcription factor.

@article{Graden1997CoppermediatedRO,
  title={Copper-mediated repression of the activation domain in the yeast Mac1p transcription factor.},
  author={Janet A. Graden and Dennis R Winge},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 11},
  pages={5550-5}
}
The expression of a number of genes encoding products involved in copper ion uptake in yeast is specifically inhibited by copper ions. We show here that copper metalloregulation occurs through Cu-dependent repression of the transactivation activity of Mac1p. A segment of the yeast transcription factor Mac1p was identified that activated transcription in vivo in a heterologous system using fusion polypeptides with the yeast Gal4 DNA-binding domain. The Gal4/Mac1p hybrid exhibits transactivation… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 27 extracted citations

Similar Papers

Loading similar papers…