Copper-mediated DNA damage by metabolites of p-dichlorobenzene.

  title={Copper-mediated DNA damage by metabolites of p-dichlorobenzene.},
  author={Susumu Oikawa and Shosuke Kawanishi},
  volume={17 12},
p-Dichlorobenzene (p-DCB) has been reported to be carcinogenic for rodents, although it does not seem to be mutagenic in bacterial test systems. In this study, the mechanism of DNA damage by metabolites of p-DCB in the presence of metals was investigated by a DNA sequencing technique using 32P-labeled DNA fragments and by an electrochemical detector coupled to an HPLC. 2,5-Dichlorohydroquinone (DCHQ), one of the major metabolites, caused DNA damage in the presence of Cu(II). 2,5-Dichloro-p… CONTINUE READING


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