Copper isotope effect in serum of cancer patients. A pilot study.

  title={Copper isotope effect in serum of cancer patients. A pilot study.},
  author={Philippe Telouk and Alain Puisieux and Toshiyuki Fujii and Vincent Balter and Victor P Bondanese and Anne Pierre Morel and Gilles Clapisson and Aline Lamboux and Francis Albar{\`e}de},
  journal={Metallomics : integrated biometal science},
  volume={7 2},
The isotope effect describes mass-dependent variations of natural isotope abundances for a particular element. In this pilot study, we measured the (65)Cu/(63)Cu ratios in the serums of 20 breast and 8 colorectal cancer patients, which correspond to, respectively, 90 and 49 samples taken at different times with molecular biomarker documentation. Copper isotope compositions were determined by multiple-collector inductively coupled plasma mass spectrometry (MC-ICP-MS). When compared with the… 

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