Copper is required for cobalt-induced transcriptional activity of hypoxia-inducible factor-1.


Cobalt inhibits prolyl hydroxylases, leading to the accumulation of hypoxia-inducible factor-1α (HIF-1α) and a concomitant increase in the transcriptional activity of HIF-1. Therefore, cobalt has been under development as a drug for activating HIF-1 under some disease conditions. However, it has been shown that ischemic conditions resulted in the loss of… (More)
DOI: 10.1124/jpet.112.194662