Copper ions potentiate a decrease in the mitochondrial membrane potential in cultured cerebellar granule neurons during glucose deprivation

Abstract

We showed that glucose deprivation for 35 min induces a decrease in the mitochondrial membrane potential in cultured cerebellar granule neurons, which was enhanced in the presence of 10 μM copper ions (Cu2+). It was associated with an increase in the free-radical level that was not affected by the noncompetitive antagonist of glutamate NMDA receptors MK-801, which prevents subsequently developing neuronal loss. However, in the presence of glucose, Cu2+ did not affect cell viability. Thus, Cu2+ induced stronger oxidative stress during glucose deprivation than in the presence of glucose, which, in turn, results in mitochondrial damage, glutamate release, glutamate receptor hyperstimulation, and neuronal loss.

DOI: 10.1134/S1819712417020040

3 Figures and Tables

Cite this paper

@article{Genrikhs2017CopperIP, title={Copper ions potentiate a decrease in the mitochondrial membrane potential in cultured cerebellar granule neurons during glucose deprivation}, author={Elisaveta E Genrikhs and Elena V. Stelmashook and V. B. Turovetskii and Leonid G Khaspekov and Nikolay K. Isaev}, journal={Neurochemical Journal}, year={2017}, volume={11}, pages={157-160} }