Copper ions disrupt dopamine metabolism via inhibition of V-H+-ATPase: a possible contributing factor to neurotoxicity.

@article{Wimalasena2007CopperID,
  title={Copper ions disrupt dopamine metabolism via inhibition of V-H+-ATPase: a possible contributing factor to neurotoxicity.},
  author={D Shyamali Wimalasena and Thomas J Wiese and Kandatege Wimalasena},
  journal={Journal of neurochemistry},
  year={2007},
  volume={101 2},
  pages={313-26}
}
The involvement of copper in the pathophysiology of neurodegeneration has been well documented but is not fully understood. Commonly, the effects are attributed to increased reactive oxygen species (ROS) production due to inherent redox properties of copper ions. Here we show copper can have physiological effects distinct from direct ROS production. First, we show that extragranular free copper inhibits the vesicular H(+)-ATPase of resealed chromaffin granule ghosts. Extragranular ascorbate… CONTINUE READING

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