Copper homeostasis at the host-pathogen interface.

  title={Copper homeostasis at the host-pathogen interface.},
  author={Victoria L. Hodgkinson and Michael J. Petris},
  journal={The Journal of biological chemistry},
  volume={287 17},
The trace element copper is indispensable for all aerobic life forms. Its ability to cycle between two oxidation states, Cu(1+) and Cu(2+), has been harnessed by a wide array of metalloenzymes that catalyze electron transfer reactions. The metabolic needs for copper are sustained by a complex series of transporters and carrier proteins that regulate its intracellular accumulation and distribution in both pathogenic microbes and their animal hosts. However, copper is also potentially toxic due… CONTINUE READING
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