Copper homeostasis and aging in the fungal model system Podospora anserina: differential expression of PaCtr3 encoding a copper transporter.

@article{Borghouts2002CopperHA,
  title={Copper homeostasis and aging in the fungal model system Podospora anserina: differential expression of PaCtr3 encoding a copper transporter.},
  author={Corina Borghouts and Christian Quintus Scheckhuber and Oliver Stephan and Heinz D. Osiewacz},
  journal={The international journal of biochemistry & cell biology},
  year={2002},
  volume={34 11},
  pages={1355-71}
}
Lifespan extension of Podospora anserina mutant grisea is caused by a loss-of-function mutation in the nuclear gene Grisea. This gene encodes the copper regulated transcription factor GRISEA recently shown to be involved in the expression of PaSod2 encoding the mitochondrial manganese superoxide dismutase. Here we report the identification and characterization of a second target gene. This gene, PaCtr3, encodes a functional homologue of the Saccharomyces cerevisiae high affinity copper permease… CONTINUE READING

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