Copper-free palladium-catalyzed Sonogashira coupling-annulation: efficient one-pot synthesis of functionalized pyrano[4,3-b]quinolines from 2-chloro-3-formylquinolines.

@article{Chandra2009CopperfreePS,
  title={Copper-free palladium-catalyzed Sonogashira coupling-annulation: efficient one-pot synthesis of functionalized pyrano[4,3-b]quinolines from 2-chloro-3-formylquinolines.},
  author={Atish Chandra and Bhawana Komal Singh and Ranjana S. Khanna and Radhey Mohan Singh},
  journal={The Journal of organic chemistry},
  year={2009},
  volume={74 15},
  pages={
          5664-6
        }
}
A convenient, one-pot, copper-free, Pd-catalyzed methodology has been described for the synthesis of 1,3-disubstituted pyrano[4,3-b]quinolines from 2-chloro-3-formylquinolines. Formation of annulated products 3 is attributed to the presence of Pd(OAc)2 and PPh3. Further, PPh3 in the reaction mixture promotes the cyclization by reducing the reaction time and increasing the yield of cyclized product. 
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