Copper-facilitated Suzuki reactions: application to 2-heterocyclic boronates.

@article{Deng2009CopperfacilitatedSR,
  title={Copper-facilitated Suzuki reactions: application to 2-heterocyclic boronates.},
  author={James Z Deng and Daniel V Paone and Anthony T Ginnetti and Hideki Kurihara and Spencer D Dreher and Steven A Weissman and Shaun R. Stauffer and Christopher S Burgey},
  journal={Organic letters},
  year={2009},
  volume={11 2},
  pages={345-7}
}
The palladium-catalyzed Suzuki-Miyaura reaction has been utilized as one of the most powerful methods for C-C bond formation. However, Suzuki reactions of electron-deficient 2-heterocyclic boronates generally give low conversions and remain challenging. The successful copper(I) facilitated Suzuki coupling of 2-heterocyclic boronates that is broad in scope is reported. Use of this methodology affords greatly enhanced yields of these notoriously difficult couplings. Furthermore, mechanistic… CONTINUE READING

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