Copper depletion down-regulates expression of the Alzheimer's disease amyloid-beta precursor protein gene.

@article{Bellingham2004CopperDD,
  title={Copper depletion down-regulates expression of the Alzheimer's disease amyloid-beta precursor protein gene.},
  author={Shayne A. Bellingham and Debomoy K. Lahiri and Bryan Maloney and Sharon La Fontaine and Gerhard Multhaup and James Camakaris},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 19},
  pages={20378-86}
}
Alzheimer's disease is characterized by the accumulation of amyloid-beta peptide, which is cleaved from the amyloid-beta precursor protein (APP). Reduction in levels of the potentially toxic amyloid-beta has emerged as one of the most important therapeutic goals in Alzheimer's disease. Key targets for this goal are factors that affect the regulation of the APP gene. Recent in vivo and in vitro studies have illustrated the importance of copper in Alzheimer's disease neuropathogenesis and… CONTINUE READING