Copper-dependent amino oxidase 3 governs selection of metabolic fuels in adipocytes

@article{Yang2018CopperdependentAO,
  title={Copper-dependent amino oxidase 3 governs selection of metabolic fuels in adipocytes},
  author={Haojun Yang and M. Ralle and M. Wolfgang and Neha Dhawan and Jason Lee Burkhead and Susana Rodriguez and J. Kaplan and G. W. Wong and N. Haughey and S. Lutsenko},
  journal={PLoS Biology},
  year={2018},
  volume={16}
}
Copper (Cu) has emerged as an important modifier of body lipid metabolism. [...] Key Result Differentiating adipocytes increase their Cu uptake along with the ATP7A-dependent transport of Cu into the secretory pathway to activate a highly up-regulated amino-oxidase copper-containing 3 (AOC3)/semicarbazide-sensitive amine oxidase (SSAO); in vivo, the activity of SSAO depends on the organism's Cu status.Expand
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