Copper deficiency in the young bovine results in dramatic decreases in brain copper concentration but does not alter brain prion protein biology.

Abstract

An Mn for Cu substitution on cellular prion proteins (PrP(c)) in the brain that results in biochemical changes to PrP(c) has been implicated in the pathogenesis of transmissible spongiform encephalopathies. Recent research in the mature bovine does not support this theory. The present study tested this hypothesis by using progeny from gestating cows… (More)
DOI: 10.2527/jas.2007-0403

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@article{Legleiter2008CopperDI, title={Copper deficiency in the young bovine results in dramatic decreases in brain copper concentration but does not alter brain prion protein biology.}, author={Leon R Legleiter and Jerry Spears and Hsiao-Ching Liu}, journal={Journal of animal science}, year={2008}, volume={86 11}, pages={3069-78} }