Copper chelation by trientine dihydrochloride inhibits liver RFA-induced inflammatory responses in vivo

@article{Yin2016CopperCB,
  title={Copper chelation by trientine dihydrochloride inhibits liver RFA-induced inflammatory responses in vivo},
  author={Ji-ming Yin and Li-bo Sun and Jia-sheng Zheng and Xin-xin Wang and De-xi Chen and Ning Li},
  journal={Inflammation Research},
  year={2016},
  volume={65},
  pages={1009-1020}
}
Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third most common cause of cancer-related death worldwide. Radiofrequency ablation (RFA) is currently performed widely for managing HCC. RFA treatment causes damage around the ablation. Trientine dihydrochloride has been used to reduce the copper in liver. The rats were treated with trientine dihydrochloride for 5 days before liver RFA. Liver function, copper concentration, inflammation biomarkers and MDA, SOD were analyzed… CONTINUE READING