Copper-catalyzed synthesis of α-hydroxy phosphonates from H-phosphonates and alcohols or ethers.

a-Hydroxy phosphonates have attracted considerable attention owing to their critical roles in anticancer drugs, plant growth regulators, and enzyme inhibitors. The traditional way to synthesize a-hydroxy phosphonates is an addition reaction of monobasic phosphorus (the Pudovik reaction) or odorous trialkyl phosphite (the Abramov reaction) to an aldehyde or… CONTINUE READING