Copper-catalyzed intramolecular trifluoromethylation of N-benzylacrylamides coupled with dearomatization: access to CF3-containing 2-azaspiro[4.5]decanes.

  title={Copper-catalyzed intramolecular trifluoromethylation of N-benzylacrylamides coupled with dearomatization: access to CF3-containing 2-azaspiro[4.5]decanes.},
  author={Guifang Han and Yuxiu Liu and Qingmin Wang},
  journal={Organic letters},
  volume={16 12},
Copper-catalyzed intramolecular trifluoromethylation of N-benzylacrylamides coupled with dearomatization was achieved and used to regiospecifically construct a variety of trifluoromethylated 2-azaspiro[4.5]decanes bearing adjacent quaternary stereocenters under mild conditions in moderate to excellent yields. 
57 Citations
Copper‐Catalyzed Intramolecular Trifluoromethylation of N‐Benzylacrylamides Coupled with Dearomatization: Access to CF3‐Containing 2‐Azaspiro[4.5]decanes.
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