Copper-catalyzed intermolecular asymmetric propargylic dearomatization of indoles.

@article{Shao2015CoppercatalyzedIA,
  title={Copper-catalyzed intermolecular asymmetric propargylic dearomatization of indoles.},
  author={W. L. Shao and He Li and Chuan Liu and Chenjiang Liu and Shu‐Li You},
  journal={Angewandte Chemie},
  year={2015},
  volume={54 26},
  pages={
          7684-7
        }
}
The first copper-catalyzed intermolecular dearomatization of indoles by an asymmetric propargylic substitution reaction was developed. This method provides a highly efficient synthesis of versatile furoindoline and pyrroloindoline derivatives containing a quaternary carbon stereogenic center and a terminal alkyne moiety with up to 86 % yield and 98 % ee. 
109 Citations
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TLDR
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TLDR
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TLDR
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TLDR
The utilization of copper-catalyzed asymmetric propargylation to install a terminal alkyne handle on indolizine heterocycle is reported.
Efficient Synthesis of N-Alkylated 4-Pyridones by Copper-Catalyzed Intermolecular Asymmetric Propargylic Amination.
TLDR
Copper-catalyzed intermolecular asymmetric propargylic amination with 4-hydroxypyridines has been realized for the first time and can be easily transformed to the core structure of quinolizidine alkaloids.
Spirooxindole synthesis via palladium-catalyzed dearomative reductive-Heck reaction.
Palladium-catalyzed intramolecular dearomative reductive-Heck reaction of C2-substituted indoles is developed, which provides access to structurally diverse 3,2'-spiropyrrolidine oxindoles. By
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