Copper-catalyzed intermolecular and regioselective aminofluorination of styrenes: facile access to β-fluoro-N-protected phenethylamines.

Abstract

A copper-catalyzed regio- and intermolecular aminofluorination of styrenes has been developed. In this reaction Ph-I=N-Ts and Et3N·3HF act as nitrogen and fluorine sources, respectively. The obtained β-fluoro-N-Ts-phenethylamines can be N-alkylated with subsequent deprotection affording the corresponding β-fluoro-N-alkylated phenethylamines, which are interesting building blocks for compounds acting on neuronal targets.

DOI: 10.1039/c4cc10162f

Cite this paper

@article{SaavedraOlavarra2015CoppercatalyzedIA, title={Copper-catalyzed intermolecular and regioselective aminofluorination of styrenes: facile access to β-fluoro-N-protected phenethylamines.}, author={Jorge Saavedra-Olavarr{\'i}a and Gean C Arteaga and Jhon J L{\'o}pez and Edwin G. P{\'e}rez}, journal={Chemical communications}, year={2015}, volume={51 16}, pages={3379-82} }