Copper catalyzed asymmetric propargylation of aldehydes.

@article{Fandrick2010CopperCA,
  title={Copper catalyzed asymmetric propargylation of aldehydes.},
  author={Daniel R Fandrick and K. Fandrick and J. T. Reeves and Z. Tan and W. Tang and Andrew G. Capacci and S. Rodrı́guez and J. Song and Heewon Lee and N. Yee and C. Senanayake},
  journal={Journal of the American Chemical Society},
  year={2010},
  volume={132 22},
  pages={
          7600-1
        }
}
The highly enantio- and regioselective copper catalyzed asymmetric propargylation of aldehydes with a propargyl borolane reagent is reported. The methodology demonstrated broad functional group tolerance and provided high enantioselectivities for aliphatic, vinyl, and aryl aldehydes. The utility of the TMS homopropargylic alcohols was demonstrated by the facile conversion to a chiral dihydropyranone. 
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