Copper-catalyzed amination of (bromophenyl)ethanolamine for a concise synthesis of aniline-containing analogues of NMDA NR2B antagonist ifenprodil.

@article{Bouteiller2010CoppercatalyzedAO,
  title={Copper-catalyzed amination of (bromophenyl)ethanolamine for a concise synthesis of aniline-containing analogues of NMDA NR2B antagonist ifenprodil.},
  author={C{\'e}dric Bouteiller and Javier Becerril-Ortega and P. Marchand and O. Nicole and L. Barr{\'e} and A. Buisson and C. Perrio},
  journal={Organic & biomolecular chemistry},
  year={2010},
  volume={8 5},
  pages={
          1111-20
        }
}
An operationally simple and concise synthesis of anilinoethanolamines, as NMDA NR2B receptor antagonist ifenprodil analogues, was developed via a copper-catalyzed amination of the corresponding bromoarene. Coupling was achieved with linear primary alkylamines, alpha,omega-diamines, hexanolamine and benzophenone imine, as well as with aqueous ammonia, in good yields using CuI and N,N-diethylsalicylamide, 2,4-pentadione or 2-acetylcyclohexanone as catalytic systems. Amination with ethylene… Expand
32 Citations
...
1
2
3
4
...

References

SHOWING 1-10 OF 77 REFERENCES
...
1
2
3
4
5
...