Copper-catalyzed aerobic oxidative amination of sp3 C-H bonds: efficient synthesis of 2-hetarylquinazolin-4(3H)-ones.

Abstract

An efficient synthesis of 2-hetarylquinazolin-4(3H)-ones via copper-catalyzed direct aerobic oxidative amination of sp(3)C-H bonds has been developed. This tandem oxidation-amination-cyclization transformation represents a straightforward protocol to prepare 2-hetaryl-substituted quinazolinones from easily available 2-aminobenzamides and (2-azaaryl)methanes… (More)
DOI: 10.1021/ol501454j

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@article{Li2014CoppercatalyzedAO, title={Copper-catalyzed aerobic oxidative amination of sp3 C-H bonds: efficient synthesis of 2-hetarylquinazolin-4(3H)-ones.}, author={Qiang Li and Yao Huang and Tieqiao Chen and Yongbo Zhou and Qing Xu and Shuang-Feng Yin and Li-Biao Han}, journal={Organic letters}, year={2014}, volume={16 14}, pages={3672-5} }