Copper binding to PrPC may inhibit prion disease propagation.

@article{Hijazi2003CopperBT,
  title={Copper binding to PrPC may inhibit prion disease propagation.},
  author={Nuha Hijazi and Yuval Shaked and Hana Rosenmann and Tamir Ben-Hur and Ruth Gabizon},
  journal={Brain research},
  year={2003},
  volume={993 1-2},
  pages={192-200}
}
Although it has been well established that PrP(C), the normal isoform of PrP(Sc), is a copper-binding protein, the role of this metal in the function of PrP(C) as well as in prion disease pathology remains unclear. Here, we show that when scrapie-infected neuroblastoma cells were cultured in the presence of copper, the accumulation of PrP(Sc) in these cells was markedly reduced. In addition, our results indicate that when normal neuroblastoma cells were cultured in the presence of copper ions… CONTINUE READING

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