Copper-binding proteins in human erythrocytes: Searching for potential biomarkers of copper over-exposure

@article{Speisky2003CopperbindingPI,
  title={Copper-binding proteins in human erythrocytes: Searching for potential biomarkers of copper over-exposure},
  author={Hern{\'a}n Speisky and Paola Navarro and M. George Cherian and In{\'e}s Maria Jim{\'e}nez},
  journal={Biometals},
  year={2003},
  volume={16},
  pages={113-123}
}
The recognition that copper is essential but also potentially toxic to humans has prompted the search for biomarkers of copper excess. The experimental approach followed here involves the isolation and subsequent characterization of copper-binding molecules (CuBP) from human erythrocytes. Incubation (0–60 min) of freshly obtained erythrocytes in the presence of increasing concentrations of copper (10–50 μM; as 64Cu-histidine) led to time- and concentration-dependent uptake of the radioisotope… CONTINUE READING
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