Copper binding in IscA inhibits iron-sulphur cluster assembly in Escherichia coli.

@article{Tan2014CopperBI,
  title={Copper binding in IscA inhibits iron-sulphur cluster assembly in Escherichia coli.},
  author={Guoqiang Tan and Zishuo Cheng and Yilin Pang and Aaron P. Landry and Jianghui Li and Jian-xin Lu and Huangen Ding},
  journal={Molecular microbiology},
  year={2014},
  volume={93 4},
  pages={629-44}
}
Among the iron-sulphur cluster assembly proteins encoded by gene cluster iscSUA-hscBA-fdx in Escherichia coli, IscA has a unique and strong iron binding activity and can provide iron for iron-sulphur cluster assembly in proteins in vitro. Deletion of IscA and its paralogue SufA results in an E. coli mutant that fails to assemble [4Fe-4S] clusters in proteins under aerobic conditions, suggesting that IscA has a crucial role for iron-sulphur cluster biogenesis. Here we report that among the iron… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 74 references

The iron-sulfur clusters of dehydratases are primary intracellular targets of copper toxicity.

Proceedings of the National Academy of Sciences of the United States of America • 2009
View 16 Excerpts
Highly Influenced

In vivo iron-sulfur cluster formation.

Proceedings of the National Academy of Sciences of the United States of America • 2008
View 10 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…