Copper availability contributes to iron perturbations in human nonalcoholic fatty liver disease.

@article{Aigner2008CopperAC,
  title={Copper availability contributes to iron perturbations in human nonalcoholic fatty liver disease.},
  author={Elmar S Aigner and Igor M Theurl and Heike Haufe and Markus Seifert and Florian Hohla and Ludwig Scharinger and Felix Stickel and Fr{\'e}d{\'e}ric Mourlane and Guenter Weiss and Christian Datz},
  journal={Gastroenterology},
  year={2008},
  volume={135 2},
  pages={680-8}
}
BACKGROUND & AIMS Iron perturbations are frequently observed in nonalcoholic fatty liver disease (NAFLD). We aimed to investigate a potential association of copper status with disturbances of iron homeostasis in NAFLD. METHODS We retrospectively studied 140 NAFLD patients and 25 control subjects. Biochemical and hepatic iron and copper parameters were analyzed. Hepatic expression of iron regulatory molecules was investigated in liver biopsy specimens by reverse-transcription polymerase chain… CONTINUE READING
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