Copper and Zinc Binding to Amyloid‐β: Coordination, Dynamics, Aggregation, Reactivity and Metal‐Ion Transfer

@article{Faller2009CopperAZ,
  title={Copper and Zinc Binding to Amyloid‐$\beta$: Coordination, Dynamics, Aggregation, Reactivity and Metal‐Ion Transfer},
  author={P. Faller},
  journal={ChemBioChem},
  year={2009},
  volume={10}
}
  • P. Faller
  • Published 2009
  • Chemistry, Medicine
  • ChemBioChem
The metal ions copper, zinc and iron have been shown to be involved in Alzheimer's disease (AD). Cu, Zn and Fe ions are proposed to be implicated in two key steps of AD pathology: 1) aggregation of the peptide amyloid‐β (Aβ), and 2) production of reactive oxygen species (ROS) induced by Aβ. There is compelling evidence that Cu and Zn bind directly to Aβ in AD. This formation of Cu/Zn–Aβ complexes is thought to be aberrant as they have been detected only in AD, but not under healthy conditions… Expand
Zinc-mediated modulation of the configuration and activity of complexes between copper and amyloid-β peptides.
  • L. Liu, N. Xia
  • Chemistry, Medicine
  • Biochemical and biophysical research communications
  • 2012
Metal-associated amyloid-β species in Alzheimer's disease.
Probing copper/tau protein interactions electrochemically.
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